The dose of COREG should not be increased until symptoms of worsening heart failure or vasodilation have been stabilized.įluid retention (with or without transient worsening heart failure symptoms) should be treated by an increase in the dose of diuretics. Vasodilatory symptoms often do not require treatment, but it may be useful to separate the time of dosing of COREG from that of the ACE inhibitor or to reduce temporarily the dose of the ACE inhibitor. During these periods, patients should avoid situations such as driving or hazardous tasks, where symptoms could result in injury. Patients should be advised that initiation of treatment and (to a lesser extent) dosage increases may be associated with transient symptoms of dizziness or lightheadedness (and rarely syncope) within the first hour after dosing.
A maximum dose of 50 mg twice daily has been administered to patients with mild-to-moderate heart failure weighing over 85 kg (187 lbs). Patients should be maintained on lower doses if higher doses are not tolerated. If tolerated, patients may have their dose increased to 6.25, 12.5, and 25 mg twice daily over successive intervals of at least 2 weeks. The recommended starting dose of COREG is 3.125 mg twice daily for 2 weeks. Prior to initiation of COREG, it is recommended that fluid retention be minimized. Heart FailureĭOSAGE MUST BE INDIVIDUALIZED AND CLOSELY MONITORED BY A PHYSICIAN DURING UP-TITRATION. It is freely soluble in dimethylsulfoxide soluble in methylene chloride and methanol sparingly soluble in 95% ethanol and isopropanol slightly soluble in ethyl ether and practically insoluble in water, gastric fluid (simulated, TS, pH 1.1), and intestinal fluid (simulated, TS without pancreatin, pH 7.5).ĬOREG should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic effects. Inactive ingredients consist of colloidal silicon dioxide, crospovidone, hypromellose, lactose, magnesium stearate, polyethylene glycol, polysorbate 80, povidone, sucrose, and titanium dioxide.Ĭarvedilol is a white to off-white powder with a molecular weight of 406.5 and a molecular formula of C 24H 26N 2O 4. The 6.25-mg, 12.5-mg, and 25-mg tablets are TILTAB tablets. Carvedilol is a racemic mixture with the following structure:ĬOREG is a white, oval, film-coated tablet containing 3.125 mg, 6.25 mg, 12.5 mg, or 25 mg of carvedilol. DESCRIPTIONĬarvedilol is a nonselective β-adrenergic blocking agent with α 1-blocking activity. You may report side effects to FDA at 1-80. For more information, ask your doctor or pharmacist.Ĭall your doctor for medical advice about side effects. These are not all the possible side effects of Coreg. Tell the doctor if you have any side effect that bothers you or that does not go away. The most common side effects of Coreg include: Get medical help right away, if you have any of the symptoms listed above. cold feeling or numbness in your fingers or toes,.What are the possible side effects of Coreg?Ĭoreg may cause serious side effects including: It is not known if Coreg is safe and effective in children. Coreg may be used alone or with other medications.Ĭoreg belongs to a class of drugs called Beta-Blockers, Alpha Activity. Childe and Ayato in particular work well with this.Find Lowest Prices on What is Coreg and how is it used?Ĭoreg is a prescription medicine used to treat the symptoms of heart failure and high blood pressure (hypertension). The 4-Piece Set will require your character to stay on the field after they use their Elemental Skill to get the most out of its affect. The increase in Hydro DMG will apply to all their attacks that are Hydro-based. The Heart of Depth's 2-Piece Set is a must-have for any DPS Hydro character. Recommended Characters - Breakdown Best For Hydro Characters
A great set for Main DPS Candace since it increases Normal Attacks.
#To heart 2 best route full
Barbara can take advantage of the full set for a Main DPS build The two piece set can be paired with either the Tenacity of Millelth or Noblesse Oblige for Yelan
The full set is recommended if you're running Mona as a Main DPS For a Burst Sub-DPS build, you can pair the two-piece set with Noblesse Oblige Pair the two-piece set with Noblesse Oblige for a Burst DPS Build This should increase his Normal Attack spam after using his Elemental Skill The full set will work well with Childe since his main attack cycle revolves around his Elemental Skill then using Normal attacks Can be paired with Noblesse Oblige for Burst DPS build 2-piece set will increase overall DMG for Childe.
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